Thermo Fisher Scientific DUT Polyclonal Antibody
Thermo Fisher Scientific의 DUT 폴리클로날 항체는 인간 DUT 단백질에 특이적으로 반응하며 IHC(P) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제된 액상 형태이며, PBS 버퍼와 글리세롤로 안정화되어 있습니다. 연구용으로만 사용 가능합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:1,000–1:2,500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein corresponding to Human DUT. Recombinant protein control fragment (Product #RP-103372). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856912 |
Product Specific Information
Immunogen sequence:
ETPAISPSKR ARPAEVGGMQ LRFARLSEHA TAPTRGSARA AGYDLYSAYD YTIPPMEKAV VKTDIQIALP SGCYGRVAPR
Target Information
This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate.
This reaction serves two cellular purposes:
- Providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication.
- Limiting intracellular pools of dUTP.
Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death.
Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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