Thermo Fisher Scientific CDK4 Monoclonal Antibody (2G7)

Applications

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
KPLFCGNSEA DQLGKIFDLI GLPPEDDWPR DVSLPRGAFP PRGPRPVQSV VPEMEESGAQ LLLEMLTFNP HKRISAFRAL QHSYLHKDEG NPE

Target Information

CDK4/cyclin D3 serine/threonine kinase is a dimeric protein complex. CDK4 is a member of the cyclin-dependent protein kinase family and plays a key role in controlling cell proliferation during the G1 phase of the cell cycle. It forms a complex with D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2). CDK4 mediates phosphorylation of the C-terminal region of the Rb protein, leading to active transcriptional repression of the E2F complex. CDC37 and HSP90 preferentially associate with CDK4 not bound to D-type cyclins. SMAD3 is a major physiological substrate of the G1 cyclin-dependent kinases CDK4 and CDK2. Although CDK6 and CDK4 both phosphorylate multiple residues in the Rb protein, they exhibit different residue selectivity in vitro: CDK6 phosphorylates Thr821, while CDK4 phosphorylates Thr826 on Rb protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.