Thermo Fisher Scientific Phospho-p21 (Thr145) Polyclonal Antibody
Phospho-p21 (Thr145) 폴리클로날 항체로 p21 단백질의 Thr145 인산화 부위를 특이적으로 인식합니다. Western blot과 IHC(Paraffin)에서 검증된 항체로, 세포 주기 조절 및 DNA 손상 반응 연구에 적합합니다. Thermo Fisher Scientific 제공.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human p21Cip1 around the phosphorylation site of Thr145 (R-Q-TP-S-M) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554746 |
Target Information
Protein p21 is a tumor suppressor protein that inhibits Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53.
p21 plays a key role in cellular response to genotoxic stress and is a major transcriptional target of p53.
In the nucleus, p21 binds and inhibits CDK1 and CDK2, blocking cell cycle progression from G1 to S phase or G2 to mitosis after DNA damage, allowing DNA repair.
In the cytoplasm, p21 has anti-apoptotic effects by binding and inhibiting caspase 3, ASK1, and JNK.
It exhibits dual roles in carcinogenesis, functioning both as a tumor suppressor and as an oncogene depending on context.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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