Thermo Fisher Scientific Contactin 2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

• Positive Control: Mouse cerebellum tissue lysate, human brain tissue lysate, rat cerebellum tissue lysate, F9
• Subcellular Location: Cell membrane

Target Information

Contactin 2 (CNTN2, transiently-expressed axonal glycoprotein, AXT, TAX, TAX1, TAG-1, axonin 1) is a neuronal cell adhesion molecule (CAM) that influences the formation of axon connections in the developing nervous system.
Contactin 2 is a member of the immunoglobulin superfamily (IgSF) and contains a glycosylphosphatidylinositol-anchor, six immunoglobulin (Ig)-like and four Fibronectin type III (FNIII)-like domains.
It is expressed predominantly during neural development on the cell membrane of axons in nerve fiber tracts to guide commissural axons without promoting their growth.
Contactin 2 binds with NgCAM in the same membrane (cis-binding). The heterophilic (Contactin 2/NgCAM and Contactin 2/NrCAM) binding sites are localized to the first four Ig domains, while the homophilic (Contactin 2/Contactin 2) binding site is localized to the FNIII domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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