Thermo Fisher Scientific CD11c Monoclonal Antibody (N418), eBioscience
Mouse CD11c 단백질을 인식하는 N418 단클론 항체로, Flow Cytometry, IHC, IP 등에 사용 가능. 다양한 형광 및 효소 표지 형식 제공. 0.5 mg/mL 액상 형태, 4°C 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | 2 |
| Immunohistochemistry (IHC) | - | 47 |
| IHC (Paraffin) | - | 1 |
| IHC (Frozen) | Assay-Dependent | 13 |
| Immunocytochemistry (ICC/IF) | - | 11 |
| Flow Cytometry (Flow) | 1 µg/test | 313 |
| ELISA | - | 1 |
| Immunoprecipitation (IP) | Assay-Dependent | - |
| In vitro Assay (IV) | - | 1 |
| Miscellaneous (PubMed) | - | 2 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Human, Mouse, Non-human primate |
| Host / Isotype | Armenian hamster / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N418 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_467114 |
Available Conjugated Formats
- Alexa Fluor 488, 532, 660, 700
- APC, APC-eFluor 780
- Biotin
- Brilliant UV 395, 496, 563, 615, 661, 737, 805
- Brilliant Violet 421, 605, 650, 711
- eFluor 450, 506, 615, 660
- FITC
- Functional Grade
- NovaFluor Blue 510, 610-30S, 660-40S, 690
- NovaFluor Yellow 570
- PE, PE-Cyanine5, PE-Cyanine5.5, PE-Cyanine7, PE-eFluor 610
- PerCP-Cyanine5.5
- Super Bright 436, 600, 645, 780
- Custom conjugation available upon request
Product Specific Information
Description:
The N418 monoclonal antibody reacts with mouse CD11c (integrin alphaX). CD11c associates with beta2 integrin (CD18) to form the CD11c/CD18 heterodimer. It is expressed by dendritic cells, subsets of intestinal intraepithelial lymphocytes, and some activated T cells. CD11c/CD18 binds CD54, iC3b, and fibrinogen, playing a role in leukocyte adhesion. N418 binds CD11c on splenic dendritic cells in T-dependent spleen areas and precipitates a 150/90 kDa heterodimer.
Applications Reported:
Flow cytometry, immunoprecipitation, and immunohistochemistry (frozen sections).
Applications Tested:
Tested by flow cytometric analysis of mouse splenocytes. Recommended ≤1 µg/test (100 µL final volume, 10⁵–10⁸ cells/test). Optimize concentration empirically for best results.
Purity: >90% (SDS-PAGE)
Aggregation: <10% (HPLC)
Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD11 proteins (CD11a, CD11b, CD11c) form heterodimeric adhesion molecules with CD18.
- CD11a: Expressed on B/T lymphocytes, macrophages, monocytes, neutrophils, basophils, eosinophils
- CD11b: Found on monocytes, macrophages, NK cells, some B/T cells, granulocytes
- CD11c: Expressed on monocytes, macrophages, NK cells, some granulocytes, and subsets of lymphocytes
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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