Thermo Fisher Scientific GRIP1 Polyclonal Antibody
GRIP1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat에 반응합니다. IHC(P) 및 ICC/IF에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 비결합형 액상 시약으로 연구용으로만 사용됩니다.
- 카탈로그번호
- PA578570
- 판매단위
- pk
카탈로그
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human GRIP1 (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.54 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 0.1M glycine, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2735884 |
Product Specific Information
- Predicted Reactivity: Human (100%), Zebrafish (82%)
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
Steroid and thyroid hormones and retinoic acid regulate gene expression via nuclear receptor transcription factors. Coactivators and corepressors modulate transcription activity of these receptors.
Glucocorticoid receptor interacting protein-1 (GRIP1), also known as Transcription Intermediary Factor 2 (TIF2), is part of a coactivator family including SRC-1 and AIB-1.
GRIP1 interacts with and enhances transcriptional activity of receptors for retinoic acid, retinoid X, vitamin D, mineralocorticoid, glucocorticoid, thyroid hormone, androgen, estrogen, progesterone, and PPAR.
It contains multiple LXXLL/LLXXL motifs crucial for receptor–coactivator interactions.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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