Thermo Fisher Scientific CLAC-P Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

PA1-4306 detects CLAC-P (NC2-1 region) in human and mouse samples.
This antibody has been successfully used in Western blot procedures.
By Western blot, it detects bands of 50, 70, and 100 kDa representing CLAC-P in formic acid extracts of Alzheimer’s disease brain.
The immunizing peptide corresponds to amino acid residues 171–183 of the NC2-1 region of human and mouse CLAC-P.

Target Information

Alzheimer’s disease (AD) is characterized by deposition of beta-amyloid as senile plaques and cerebral amyloid angiopathy.
The principal component of AD amyloid is the amyloid beta peptide (Aβ). Although production and deposition of Aβ appear closely related to AD pathogenesis, current evidence suggests that Aβ alone is not sufficient to cause neuronal death and dementia symptoms.

A component of senile plaque (SP), CLAC (collagen-like Alzheimer amyloid plaque component), and its precursor CLAC-P are deposited with extracellular beta-amyloid and have been implicated in cell toxicity of beta-amyloid in AD brains.
CLAC-P is a unique, membrane-bound collagen-like structure containing three Gly-X-Y repeat motifs and may define a novel class of neuronal collagens.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.