Thermo Fisher Scientific RAPGEF5 Polyclonal Antibody
RAPGEF5 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western blot에 최적화되어 있습니다. 인간, 생쥐, 랫트에 반응하며 항원 친화 크로마토그래피로 정제되었습니다. 고순도(>95%)이며 연구용으로 적합합니다.
- 카탈로그번호
- PA575558
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific RAPGEF5 Polyclonal Antibody
Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 476–521 of Human RAPGEF5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719286 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
Members of the RAS subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches cycling between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as Repac, serve as RAS activators by promoting acquisition of GTP to maintain the active state, linking cell surface receptors to RAS activation.
Repac, also known as Rap guanine nucleotide exchange factor 5 (RAPGEF5), is a 580 amino acid protein expressed in brain and testis, with weaker expression in heart, placenta, lung, pancreas, and small intestine. Existing as two alternatively spliced isoforms, the Repac gene is conserved in cow, mouse, and rat. The gene encoding Repac maps to human chromosome 7p15.3, with high expression of this region linked to positive response to erlotinib therapy in non-small-cell lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-75558_RAPGEF5_Q92565-1_Rabbit.svg, PA5-75558_RAPGEF5_Q92565-1_Rabbit_PDP.jpeg)
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