Thermo Fisher Scientific MMP12 Recombinant Rabbit Monoclonal Antibody (1O3A4)
MMP12 단백질을 인식하는 토끼 단클론 항체로, Western blot 및 ELISA에 적합. 인간, 생쥐, 랫드 시료 반응. HEK293 세포에서 발현된 recombinant antibody. 고순도 친화 크로마토그래피 정제. -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 1O3A4 |
| Immunogen | A synthetic peptide corresponding to amino acids 371–470 of human MMP12 (P39900) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911977 |
Product Specific Information
- Positive test controls: A-549, BxPC-3, Mouse lung, Mouse brain, Mouse spleen, Rat lung
- Target localization: Secreted, extracellular matrix, extracellular space
Immunogen sequence:
FGFPNFVKKI DAAVFNPRFY RTYFFVDNQY WRYDERRQMM DPGYPKLITK NFQGIGPKID AVFYSKNKYY YFFQGSNQFE YDFLLQRITK TLKSNSWFGC
Target Information
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes like arthritis and metastasis. Most MMPs are secreted as inactive proproteins, activated upon cleavage by extracellular proteinases. The MMP12 enzyme degrades soluble and insoluble elastin and may play roles in aneurysm formation and emphysema development. The gene localizes to chromosome 11q22.3.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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