Thermo Fisher Scientific MEKK1 Polyclonal Antibody
MEKK1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC(P), ICC/IF에 사용 가능. 고농도(1.53 mg/mL) 액상 형태로 제공되며, -20°C 보관. MAPK 신호전달 연구용으로 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
Product Specifications
| Item | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1400 to the C-terminus of human MAP3K1 (NP_005912.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.53 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855344 |
Product Specific Information
Sequence of this protein is as follows:
TGAGEFQGQL LGTIAFMAPE VLRGQQYGRS CDVWSVGCAI IEMACAKPPW NAEKHSNHLA LIFKIASATT APSIPSHLSP GLRDVALRCL ELQPQDRPPS RELLKHPVFR TTW
Target Information
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK).
MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK.
The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells.
MEKK1 can phosphorylate and activate MAPKK 1 and MAPKK 2 (MEK1/MEK2), leading to phosphorylation of MAP kinases.
It is also a highly efficient activator of the JNK cascade.
The protein contains a putative 1 RING-type zinc finger and 1 SWIM-type zinc finger.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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