Thermo Fisher Scientific MAF Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:2,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
HVLESEKNQL LQQVDHLKQE ISRLVRERDA YKEKYEKLVS SGFRENGSSS DNPSSPEFFI TEPTRKLEPS VGYATFWKPQ HRVLTSVFTK

Target Information

c-maf is the cellular counterpart of oncogenic v-maf that belongs to the family of basic region leucine zipper domain transcription factors. The leucine-zipper domain is involved in the interaction with LRPICD. There are two forms of human c-maf mRNA: c-maf-long and c-maf-short. It is identified in the genome of the acute transforming avian retrovirus AS42.
c-maf targets include IL-4 in Th2 cells, crystalline genes in lens fiber cells, insulin gene in islets, p53, and L7, where it exerts transcriptional regulation through binding to a Maf recognition element (MARE). It regulates Th2 differentiation and lineage-specific hematopoiesis and functions as a transcription factor for IL-10 gene expression in LPS-activated macrophages. Chromosomal aberrations involving maf are found in some forms of multiple myeloma. It is expressed in myeloma cell lines and resting monocytes/macrophages.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.