Thermo Fisher Scientific Phospho-ALK (Tyr1586) Polyclonal Antibody
Phospho-ALK (Tyr1586) 폴리클로날 항체로 인간, 마우스, 랫트 시료에 반응합니다. Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합하며, Protein A로 정제된 고순도 항체입니다. 뇌 발달 및 종양 관련 ALK 단백질 연구에 유용합니다.
- 카탈로그번호
- BS-3047R
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-ALK (Tyr1586) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human ALK around the phosphorylation site of Tyr1586 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01 M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is vital for brain development. Mutations, rearrangements, and amplifications in the ALK gene have been associated with tumors such as anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer. The most common alteration is chromosomal rearrangement resulting in a fusion gene between ALK and nucleophosmin (NPM). The NPM-ALK fusion product is oncogenic. ALK encodes a receptor tyrosine kinase with a transmembrane and extracellular domain, which are absent in the NPM-ALK fusion product. ALK shows high sequence similarity to LTK and plays a crucial role in neuronal development.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.