Thermo Fisher Scientific COX8A Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total COX8A.

Target Information

The cytochrome c oxidase (COX) family of proteins function as the final electron donor in the respiratory chain to drive a proton gradient across the inner mitochondrial membrane, ultimately resulting in the production of water and ATP.
The mammalian COX apoenzyme is a dimer, with each monomer consisting of 13 subunits, some of which are mitochondrial and some of which are nuclear.
The COX8 (cytochrome c oxidase subunit VIII) subunits are nuclear and have muscle and non-muscle-specific isoforms.
COX8 exists as three isoforms:

• COX8a: liver and heart isoform
• COX8b: heart-specific isoform
• COX8c: expression pattern not yet elucidated

All three COX8 isoforms exist as components of the COX complex and play an important role in electron transport.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.