Thermo Fisher Scientific CCBE1 Polyclonal Antibody
CCBE1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용에 적합. 인간 및 생쥐 반응성. 고순도 친화 크로마토그래피 정제. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CCBE1 (Accession Q6UXH8), corresponding to amino acid residues G155–F205 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818739 |
Product Specific Information
Antibody detects endogenous levels of total CCBE1.
Target Information
The gene encoding CCBE1 (Collagen and calcium-binding EGF domain-containing protein 1) is located on chromosome 18 in a region frequently deleted in breast and prostate cancers.
CCBE1 is a 406-amino-acid secreted protein containing two collagen-like domains and one calcium-binding EGF-like domain.
EGF-like domains typically include six cysteine residues involved in disulfide bonds. Calcium-binding EGF-like domains may undergo amino acid substitutions that alter their structure or calcium affinity, affecting protein function.
Downregulation of CCBE1 is frequently observed in breast cancer, suggesting that loss of CCBE1 impacts cell adhesion and mobility.
Three isoforms of CCBE1 are produced through alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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