Thermo Fisher Scientific MCAM (Melanoma Cell Adhesion Molecule)/MUC18/CD146 Monoclonal Antibody (SPM620)
인간 MCAM/CD146 단백질을 인식하는 단클론 항체로, IHC, ICC, Flow Cytometry 등 다양한 응용에 적합합니다. 멜라노마 세포 접착 분자 연구에 유용하며, 단백질 A/G로 정제된 고순도 항체입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM620 |
| Immunogen | Recombinant human MCAM protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
CD146 (MCAM) is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. It is expressed at cell–cell junctions in endothelial cells and in various normal and malignant cell types. CD146 functions as a calcium-independent cell adhesion molecule and may act as a signal transduction molecule by recruiting Fyn kinase, leading to tyrosine phosphorylation of intracellular proteins involved in actin cytoskeleton assembly. It plays key roles in cell adhesion, endothelial monolayer cohesion, and may facilitate melanoma cell interaction with vascular elements, promoting tumor spread. Additionally, CD146 may function as an adhesion molecule in neural crest cells during embryonic development and as a surface receptor triggering phosphorylation events and calcium signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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