Thermo Fisher Scientific KRT18 Monoclonal Antibody (OTI10H8), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Cytokeratin 18 (Keratin 18, KRT18, type I cytoskeletal 18) is a type A (acidic) low molecular weight keratin that pairs with cytokeratin 8. It is expressed in epithelial tissues of the gastrointestinal, respiratory, and urogenital tracts, as well as endocrine and exocrine tissues and mesothelial cells.
Cytokeratin 18 is primarily found in non-squamous epithelia and is present in most adenocarcinomas and ductal carcinomas, but absent in squamous cell carcinomas. Hepatocellular carcinomas express only cytokeratins 8 and 18.
Mutations in the KRT18 gene have been associated with cryptogenic cirrhosis. Two transcript variants encoding the same protein have been identified.
Cytokeratin subtype expression patterns are increasingly used to distinguish types of epithelial malignancies. Cytokeratin antibodies assist in tumor differential diagnosis via immunohistochemistry and are useful tools in cytopathology and flow cytometry assays.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.