Thermo Fisher Scientific Granzyme B Monoclonal Antibody (GB11)
상품 옵션 정보 | |||||||||
---|---|---|---|---|---|---|---|---|---|
카탈로그 번호 | CAS 번호 | 설명 | 상태 | 재고 | 단위 | 판매가 | 할인가 | 가격(VAT포함) | 수량 / 장바구니 / 찜 |
MA180734 | - | Thermo Fisher Scientific MA180734 Granzyme B Monoclonal Antibody (GB11) 100 ug pk | 재고문의 | pk | 783,000원 | - | 861,300원 |
Applications
Tested Dilution
Publications
Western Blot (WB)
1:1,000
View 1 publication 1 publication
Immunohistochemistry (IHC)
-
View 2 publications 2 publications
Immunohistochemistry (Frozen) (IHC (F))
Assay-dependent
Immunocytochemistry (ICC/IF)
1:100
View 6 publications 6 publications
Flow Cytometry (Flow)
1:10-1:100
View 44 publications 44 publications
ELISA (ELISA)
2-5 µg/mL
View 1 publication 1 publication
Immunoprecipitation (IP)
Assay-dependent
Miscellaneous PubMed (Misc)
-
View 14 publications 14 publications
Mass Spectrometry (MS)
-
View 1 publication 1 publication
Product Specifications
Species Reactivity
Human, Non-human primate, Rhesus monkey
Published species
Human, Mouse, Rhesus monkey
Host/Isotype
Mouse / IgG1
Class
Monoclonal
Type
Antibody
Clone
GB11
Immunogen
Purified human Granzyme B. if (typeof window.$mangular === undefined
|| !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{
targetFamily:
Granzyme B,
uniProtId:
P10144-1,
ncbiNodeId:
9606,
antigenRange:
1-247,
antigenLength:
247,
antigenImageFileName:
MA1-80734_Granzyme_B_P10144-1_House_mouse.svg,
antigenImageFileNamePDP:
MA1-80734_Granzyme_B_P10144-1_House_mouse_PDP.jpeg,
sortOrder:
1}\]
; $mangular.isB2BCMGT = false
; $mangular.isEpitopesModalImageMultiSizeEnabled = true
;
View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_931084
Product Specific Information
Membrane permeabilization is required for flow cytometry applications. For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.
Mouse anti Granzyme B antibody, clone GB11 recognizes the serine protease Granzyme B, which is important in the induction of apoptosis in target cells by cytolytic lymphocytes (CTLs).
Target Information
Granzyme B is a member of the granzyme serine protease family, and is found in the granules of cytotoxic T cells and NK cells. Granzyme B has been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation, and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved in this process has been identified as mannose 6-phosphate receptor which functions as a death receptor for Granzyme B during cytotoxic T cell-induced apoptosis. Granzyme B enters target cells to cleave caspase-3 and initiate the caspase cascade leading to DNA fragmentation and apoptosis. Granzyme B can also act through a mitochondrial apoptosis pathway by cleaving the Bid protein. Granzymes are neutral serine proteases, which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTLs) and in natural killer (NK) cells. A number of granzymes (A to G) have been isolated and cloned from mouse CTLs and NK cells, however in man, fewer have been cloned and identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
배송/결제/교환/반품 안내
배송 정보
기본 배송비 |
| 교환/반품 배송비 |
|
---|---|---|---|
착불 배송비 |
| ||
교환/반품 배송비 |
|
결제 및 환불 안내
결제 방법 |
|
---|---|
취소 |
|
반품 |
|
환급 |
|
교환 및 반품 접수
교환 및 반품 접수 기한 |
|
---|---|
교환 및 반품 접수가 가능한 경우 |
|
교환 및 반품 접수가 불가능한 경우 |
|
교환 및 반품 신청
교환 절차 |
|
---|---|
반품 절차 |
|