Thermo Fisher Scientific Neurofascin Polyclonal Antibody
인간 Neurofascin 단백질을 인식하는 goat polyclonal antibody로 Western blot에 최적화되어 있습니다. 다양한 isoform을 검출하며, 액상 형태로 제공됩니다. 안정적인 보관을 위한 TBS buffer와 sodium azide 포함. 연구용으로만 사용 가능합니다.
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- PA5142767
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Thermo Fisher Scientific Neurofascin Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 0.5–2 µg/mL
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-NFSPNQTKFTVQRT |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2933413 |
Product Specific Information
This antibody is expected to recognize reported isoforms 1, 2, 3, and 4 (NP_001005388.2, NP_001153803.1, NP_001153804.1, and NP_055905.2 respectively).
Tested in Peptide ELISA: antibody detection limit dilution 1:16,000.
Target Information
Neurofascin encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development.
AIS and nodes of Ranvier contain high densities of voltage-gated Na⁺ (Nav) channels, which are clustered by interactions with cytoskeletal and scaffolding proteins including Neurofascin, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin.
This protein links the AIS extracellular matrix to the intracellular cytoskeleton. Neurofascin undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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