Thermo Fisher Scientific Neurofascin Polyclonal Antibody

Thermo Fisher Scientific Neurofascin Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution: 0.5–2 µg/mL
Publications: -

Product Specifications

Product Specific Information

This antibody is expected to recognize reported isoforms 1, 2, 3, and 4 (NP_001005388.2, NP_001153803.1, NP_001153804.1, and NP_055905.2 respectively).
Tested in Peptide ELISA: antibody detection limit dilution 1:16,000.

Target Information

Neurofascin encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development.
AIS and nodes of Ranvier contain high densities of voltage-gated Na⁺ (Nav) channels, which are clustered by interactions with cytoskeletal and scaffolding proteins including Neurofascin, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin.
This protein links the AIS extracellular matrix to the intracellular cytoskeleton. Neurofascin undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.