Thermo Fisher Scientific SOD2 (MnSOD) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.01–0.1 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 5 µg/mL

Product Specifications

Product Specific Information

• The immunizing peptide represents the acetylation site including K122 according to isoform A.
• This antibody is expected to recognize both reported isoforms (NP_000627.2; NP_001019637.1).
• Tested in Peptide ELISA: antibody detection limit dilution 1:64,000.

Target Information

Superoxide dismutase (SOD) is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS).
SOD catalyzes the dismutation of superoxide radical anion (O₂⁻) to hydrogen peroxide (H₂O₂), which is further converted to O₂ and H₂O by glutathione peroxidase and catalase.
There are several classes of SOD:

• SOD1 (Cu, Zn-SOD): intracellular, homodimeric enzyme (~32 kDa)
• SOD2 (Mn-SOD): mitochondrial, tetrameric enzyme (~80 kDa)
• SOD3 (EC-SOD): extracellular, multimeric enzyme
• SOD4 (CCS): copper chaperone for SOD1 activation

SOD2 is located in the mitochondrial matrix and plays a crucial role in detoxifying superoxide generated by the respiratory chain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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