Thermo Fisher Scientific Progesterone Receptor (Marker of Progestin Dependence) Recombinant Rabbit Monoclonal Antibody (PGR/8099R)
사람 프로게스테론 수용체(PGR)를 인식하는 재조합 토끼 단클론 항체. IHC(P)에서 1–2 µg/mL 권장. 양성 대조군은 인체 유방암 조직. 핵 내 발현 확인용. 단백질 A/G 정제, 4°C 보관, 연구용 한정.
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카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Progesterone Receptor (Marker of Progestin Dependence) Recombinant Rabbit Monoclonal Antibody (PGR/8099R)
Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PGR/8099R |
| Immunogen | Recombinant fragment (around aa 1–200) of human PGR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Human breast carcinoma
- Cellular Location: Nucleus
Target Information
The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. It mediates the physiological effects of progesterone, which plays a central role in reproductive processes such as pregnancy establishment and maintenance.
PR exists as two isoforms: a 94 kDa protein (Form A) and a 120 kDa protein (Form B), produced by alternative translation initiation. PR-B is transcriptionally active, regulating genes for endometrial maintenance and inhibition of ovulation. PR-A lacks 165 amino acids at the N-terminus, exposing an inhibitory domain that represses steroid hormone transcriptional activity.
In its inactive state, PgR forms a multiprotein complex with heat shock proteins and immunophilins. Progesterone binding induces conformational changes, dimerization, and binding to progesterone response elements (PRE), resulting in activated transcription. Null mutations in the PGR gene cause reproductive abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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