Thermo Fisher Scientific Progesterone Receptor (Marker of Progestin Dependence) Recombinant Rabbit Monoclonal Antibody (PGR/6854R)
프로게스테론 수용체(PR)를 검출하는 재조합 토끼 단클론 항체로, 인간 및 말 시료에 반응합니다. IHC(P)와 IHC(PFA) 분석에 적합하며, 고순도 Protein A/G 정제 방식으로 제조되었습니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific Progesterone Receptor (Marker of Progestin Dependence) Recombinant Rabbit Monoclonal Antibody (PGR/6854R)
Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): Assay-dependent
- Immunohistochemistry (PFA fixed) (IHC (PFA)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Horse, Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PGR/6854R |
| Immunogen | Recombinant fragment (around aa 1–200) of human PGR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy.
PR exists as two forms: a 94 kDa protein (Form A) and a 120 kDa protein (Form B), generated by alternative translation initiation sites.
- PR-B: Transcriptionally active form responsible for gene activation related to endometrial maintenance, pregnancy, and ovulation inhibition.
- PR-A: Identical to PR-B except for a 165 amino acid deletion at the N-terminus, exposing a 140 amino acid inhibitory domain that represses steroid hormone transcriptional activity.
In its inactive state, PgR forms a multiprotein complex with heat shock proteins and immunophilins. Upon progesterone binding, the receptor undergoes conformational change, dimerizes, and binds to progesterone response elements (PRE) to activate transcription.
A null mutation in the PGR gene leads to pleiotropic reproductive abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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