Thermo Fisher Scientific P-glycoprotein/p170/MDR1/CD243 Recombinant Rabbit Monoclonal Antibody (MDR1/8986R)
P-glycoprotein(MDR1/CD243)을 인식하는 재조합 토끼 단일클론 항체로, IHC(P) 실험에 적합합니다. 인간 시료 반응성이 있으며, HEK293 세포에서 발현되었습니다. Protein A/G로 정제된 액상 항체로 4°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | MDR1/8986R |
| Immunogen | Recombinant fragment (around aa500–700) of human ABCB1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: hPBL or Jurkat whole cell lysate, Human adrenal gland
- Cellular Location: Membrane
Target Information
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein is a member of the MDR/TAP subfamily, involved in multidrug resistance. It functions as an ATP-dependent drug efflux pump with broad substrate specificity, responsible for decreased drug accumulation in multidrug-resistant cells and mediating resistance to anticancer drugs. It also serves as a transporter in the blood-brain barrier.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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