Thermo Fisher Scientific Desmoglein 3 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 749-999 of human Desmoglein 3 (NP_001935.2). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Desmoglein 3,uniProtId:P32926-1,ncbiNodeId:9606,antigenRange:749-999,antigenLength:999,antigenImageFileName:PA5-121194_Desmoglein_3_P32926-1_Rabbit.svg,antigenImageFileNamePDP:PA5-121194_Desmoglein_3_P32926-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.1 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2914766

Product Specific Information

Positive test controls include: HeLa, Mouse liver. The target is usually found in the following locations: Cell junction, Cell membrane, Single-pass type I membrane protein, desmosome.

Immunogen sequence: FGAATGVGIC SSGQSGTMRT RHSTGGTNKD YADGAISMNF LDSYFSQKAF ACAEEDDGQE ANDCLLIYDN EGADATGSPV GSVGCCSFIA DDLDDSFLDS LGPKFKKLAE ISLGVDGEGK EVQPPSKDSG YGIESCGHPI EVQQTGFVKC QTLSGSQGAS ALSTSGSVQP AVSIPDPLQH GNYLVTETYS ASGSLVQPST AGFDPLLTQN VIVTERVICP ISSVPGNLAG PTQLRGSHTM LCTEDPCSRL I

Target Information

Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a member of the desmosomal cadherin family and plays a critical role in cell-cell adhesion. It is predominately expressed in stratified squamous epithelium, including the skin, oral mucosa, and esophagus. Desmoglein 3 has been characterized as the auto-antigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease. Binding of anti-Desmoglein 3 autoantibodies causes the loss of cell-cell adhesion, which clinically manifests as blisters on the skin and oral mucosa, and histologically as suprabasilar acantholysis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.