Thermo Fisher Scientific SCNN1G (extracellular) Polyclonal Antibody

Applications

• Western Blot (WB): 1:200
• Immunohistochemistry (IHC): Assay-dependent

Product Specifications

Product Specific Information

• Reconstitute antibody with 50 µL of double distilled water (DDW).
• Store reconstituted solution at 4°C for up to 1 week.
• For longer storage, keep small aliquots at -20°C.
• Avoid multiple freeze-thaw cycles.
• Centrifuge all antibody preparations before use (10,000 × g, 5 min).
• Peptide sequence: (C)YGVKESR KRREAGS
• Homology: Human – 13/17 amino acid residues identical.

Target Information

Epithelial sodium channels (ENaC) are amiloride-sensitive members of the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. These channels have two short intracellular termini, two transmembrane segments, and a large extracellular loop with a conserved cysteine-rich region.
ENaC isoforms (α, β, γ) are expressed in kidney, lung, and colon, playing crucial roles in sodium and fluid balance.
ENaC mediates aldosterone-dependent sodium reabsorption in the distal nephron, regulating blood pressure.
Association with CFTR chloride channels contributes to regulation.
Mutations in ENaC subunits are linked to Liddle’s syndrome (hypertension) and pseudohypoaldosteronism (PHA-1).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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