Thermo Fisher Scientific CXXC4 Polyclonal Antibody
CXXC4 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, Flow cytometry에 사용 가능. 인간 및 생쥐 반응성. Wnt 신호전달 경로 연구에 적합하며, 단백질 발현 및 암 연구에 활용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 158–185 of the C-terminal region of human CXXC4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2543891 |
Product Specific Information
This antibody is predicted to react with rat based on sequence homology.
Target Information
CXXC4 is a zinc finger protein that binds directly to the PDZ domain of DVL1, a protein involved in the Wnt signaling pathway, through its C-terminal region. CXXC4 interaction with DVL1 competes with DVL1–AXIN binding, although the affinity of DVL1 for CXXC4 is lower than that for AXIN.
In mouse fibroblasts, CXXC4 suppresses Wnt3a induction of β-catenin and inhibits Wnt3a-dependent TCF4 activation, suggesting that CXXC4 acts as a negative regulator of the Wnt signaling pathway and functions between DVL and β-catenin.
Recent reports suggest that decreased CXXC4 expression is associated with kidney cancer metastasis, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involved in proliferation, invasion, and cell survival, indicating that CXXC4 plays a critical role in tumor progression in kidney cancer.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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