Thermo Fisher Scientific STMN4 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total STMN4.

Target Information

RB3 (Stathmin-4), encoded by the STMN4 gene, is a neuron-specific homologue of the SCG10/stathmin family proteins. It possesses a unique N-terminal membrane-associated domain and a stathmin-like domain at the C terminus, which promotes microtubule (MT) catastrophe and/or tubulin sequestering.
Stathmin is a ubiquitous cytosolic phosphoprotein, preferentially expressed in the nervous system, and described as a relay integrating diverse intracellular signaling pathways.
RB3 is consistently up-regulated in differentiated neuroblastoma cells, and stable expression of transfected RB3 could induce differentiation, suggesting a role of RB3 during neuroblastoma differentiation.
Moreover, increased RB3 is a unique response protein in the stathmin-related proteins following optical nerve axotomy and may be a critical target for neurodegenerative diseases.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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