Thermo Fisher Scientific DAB2 Polyclonal Antibody
Human DAB2 단백질에 특이적인 Rabbit Polyclonal Antibody로, WB, IHC, ICC 등 다양한 응용에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 고순도 액상 형태로 제공. 연구용으로만 사용 가능.
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Thermo Fisher Scientific DAB2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.4 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 | - |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human DAB2 (Product #RP-102273) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640364 |
Product Specific Information
Immunogen sequence:
NAFSANLNFF PTPNPDPFRD DPFTQPDQST PSSFDSLKSP DQKKENSSSS STPLSNGPLN GDVDYFGQQF DQISNRTGKQ EAQAGPWPFS SSQTQPAVRT QNGVSEREQN GFSVKSSPNP
Highest antigen sequence identity to the following orthologs:
- Mouse: 86%
- Rat: 82%
Target Information
DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines.
The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain.
The down-regulation of DAB2 may play an important role in ovarian carcinogenesis.
This gene was initially named DOC2 (Differentially expressed in Ovarian Cancer) and is distinct from DOC2A and DOC2B genes (double C2-like domains, alpha and beta).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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