Thermo Fisher Scientific KCNIP2/KCHIP2 Monoclonal Antibody (KCNIP2/7588)

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL

Product Specifications

Product Specific Information

• Positive Control: Human brain
• Cellular Location: Cell membrane

Target Information

Voltage-gated potassium (Kv) channels are essential components of potassium currents in the heart and central nervous system.

• In the heart, Kv4 channels contribute to the repolarization phase of the action potential.
• In the brain, they prevent reverse-propagation of action potentials.

Kv4 channels are associated with calcium-binding proteins known as KChIPs (Kv channel interacting proteins).
KChIPs bind to the cytoplasmic amino termini of Kv4 alpha-subunits and modulate their function.
Known KChIP family members include:

• KChIP1: Expressed in the brain
• KChIP2: Expressed in brain, heart, and lung; has three isoforms (a, b, c)
• KChIP3: Also known as calsenilin and DREAM; expressed in brain and testis

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.