
Thermo Fisher Scientific KCNIP2/KCHIP2 Monoclonal Antibody (KCNIP2/7589)
인간 KCNIP2 단백질을 인식하는 마우스 단클론 항체로, IHC(P) 분석에 적합합니다. 단백질 A/G로 정제된 액상 형태이며 4°C에서 보관합니다. 심장 및 중추신경계의 전압 개폐성 칼륨 채널 연구에 활용됩니다.
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Thermo Fisher Scientific KCNIP2/KCHIP2 Monoclonal Antibody (KCNIP2/7589)
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | KCNIP2/7589 |
| Immunogen | Recombinant fragment (around aa1–270) of human KCNIP2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Human brain
- Cellular Location: Cell membrane
Target Information
Voltage-gated potassium (Kv) channels are key components of potassium currents in the heart and central nervous system.
In the heart, Kv4 channels are involved in the repolarization phase of the action potential.
In the brain, these channels prevent reverse-propagation of action potentials.
Associated with Kv4 channels are calcium-binding proteins termed KChIPs (Kv channel interacting proteins).
KChIPs are small molecular weight proteins that bind to the cytoplasmic amino termini of Kv4 alpha-subunits and modulate their function.
Known KChIPs:
- KChIP1: Expressed in the brain
- KChIP2: Expressed in brain, heart, and lung (isoforms a, b, c)
- KChIP3: Also known as calsenilin and DREAM, expressed in brain and testis
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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