Thermo Fisher Scientific Phospho-NFkB (RelA) (Ser276) Polyclonal Antibody
인간 NFkB p65 (RelA) Ser276 인산화 형태를 특이적으로 인식하는 폴리클로날 항체. WB, IHC, ELISA, IP 등 다양한 응용 가능. 비인산화 p65에 대한 반응 최소화. -20°C에서 안정적 보관 가능.
- 카탈로그번호
- 100-401-264
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Phospho-NFkB (RelA) (Ser276) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:800 |
| ELISA | 1:10,000–1:30,000 |
| Immunoprecipitation (IP) | 1:1,000–1:5,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | NFkB p65 (RelA) peptide corresponding to an internal region near phospho Serine 276 of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 80 mg/mL |
| Storage Buffer | Whole serum |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at -20°C prior to opening.
- Aliquot contents and freeze at -20°C or below for extended storage.
- Avoid cycles of freezing and thawing.
- Centrifuge product if not completely clear after standing at room temperature.
- Stable for several weeks at 4°C as an undiluted liquid.
- Dilute only prior to immediate use.
This phospho-specific polyclonal antibody is specific for phosphorylated pS276 human p65. Reactivity with non-phosphorylated p65 is minimal. Cross-reactivity with pS276 phosphorylated p65 from mouse, rat, or other species has not been determined.
Target Information
Nuclear factor kB p65 (NF-kB p65) is encoded by the RELA gene and located on chromosome 11 in humans. Also known as RelA, it belongs to the Rel family of proteins and forms part of the NF-kB complex by heterodimerizing with p50 or p52 subunits.
Upon TNF-α binding to its receptor, IKK is phosphorylated, which subsequently phosphorylates IκB, leading to its proteasomal degradation. NF-kB p65 plays a key role in transcriptional regulation of the immunoglobulin κ gene in mature B-lymphoid cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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