Thermo Fisher Scientific CDK8 Recombinant Rabbit Monoclonal Antibody (ARC1682)
Recombinant Rabbit Monoclonal Antibody targeting CDK8 for WB and ELISA applications. Reacts with Mouse and Rat. High purity, affinity-purified, liquid form with 0.8 mg/mL concentration. Stable storage at -20°C in PBS buffer with glycerol and BSA.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Concentration: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1682 |
| Immunogen | Synthetic peptide corresponding to amino acids 1–100 of human CDK8 (UniProt ID: P49336) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.8 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849730 |
Product Specific Information
Immunogen sequence:
MDYDFKVKLS SERERVEDLF EYEGCKVGRG TYGHVYKAKR KDGKDDKDYA LKQIEGTGIS MSACREIALL RELKHPNVIS LQKVFLSHAD RKVWLLFDYA
Target Information
CDK8 phosphorylates the carboxy-terminal domain of the largest subunit of RNA polymerase II. This protein is coexpressed and copurified with Cyclin C. CDK8 belongs to the family of cyclin-dependent kinases (CDKs) that regulate cell cycle progression.
The prototype member, p34/Cdc2, and related Cdk2 function late in the cycle, while Cdk4 and Cdk6 are involved in G1 to S phase progression.
Human Cdk8–Cyclin C complex may interact with RNA polymerase, influencing transcription mechanisms that lead to cell division.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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