Thermo Fisher Scientific CaV1.2 (CACNA1C) Polyclonal Antibody, Atto 488
CaV1.2(CACNA1C) 단백질을 인식하는 Atto 488 형광 표지 폴리클로날 항체로, 인간·마우스·랫트 시료에 반응. IHC(P), IHC(F), ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 신뢰성 제공.
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Thermo Fisher Scientific CaV1.2 (CACNA1C) Polyclonal Antibody, Atto 488
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100 |
| Immunocytochemistry (ICC/IF) | 1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | (C)TTKINMDDLQPSENEDKS, corresponding to amino acid residues 848–865 of rat CaV1.2, intracellular loop between domains II and III |
| Conjugate | Atto™ 488 |
| Excitation/Emission Max | 501/523 nm |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 1% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitution: Add 50 µL double distilled water (DDW), depending on sample size.
The antibody ships as a lyophilized powder at room temperature and should be stored at -20°C upon arrival.
The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, store small aliquots at -20°C.
Avoid multiple freeze-thaw cycles. Centrifuge all antibody preparations before use (10,000 × g, 5 min).
Target Information
CACNA1C encodes an alpha-1 subunit of a voltage-dependent calcium channel. These channels mediate calcium ion influx upon membrane polarization.
The alpha-1 subunit consists of 24 transmembrane segments forming the ion passage pore.
The calcium channel complex includes alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio.
Multiple isoforms exist due to different genes or alternative splicing.
The protein encoded by CACNA1C binds to and is inhibited by dihydropyridine.
Alternative splicing generates numerous transcript variants encoding distinct proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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