Thermo Fisher Scientific ABCB11 Polyclonal Antibody
ABCB11 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 실험에 적합합니다. 인간, 생쥐, 랫트 반응성을 가지며, 고순도 Affinity Chromatography로 정제되었습니다. 액상형으로 -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ABCB11 (Accession O95342), corresponding to amino acid residues N665–V715 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852993 |
Product Specific Information
Antibody detects endogenous levels of total ABCB11.
Target Information
ABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. It is expressed predominantly in the liver, localized to the canalicular microvilli and subcanalicular vesicles of hepatocytes. Structurally, ABCB11 is a multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP-binding cassette (ABC) domain.
Defects in ABCB11 cause progressive familial intrahepatic cholestasis 2 (PFIC2), an inherited liver disease of childhood characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Mutations are also associated with chronic intrahepatic cholestasis without familial history.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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