Thermo Fisher Scientific Phospho-Androgen Receptor (Ser650) Polyclonal Antibody
Phospho-Androgen Receptor (Ser650) 폴리클로날 항체로 인간, 마우스, 랫트에 반응하며 Western Blot, IHC, ICC, Flow Cytometry, ELISA 등 다양한 응용에 적합. KLH 결합 합성 인산화 펩타이드 면역원 사용. 고순도 Protein A 정제, 액상 형태로 -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human Androgen Receptor around the phosphorylation site of Ser650 [TT(p-S)PT] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. This receptor (~90 kDa) has three major functional domains: the N-terminal domain, DNA-binding domain, and the androgen-binding domain.
AR is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and activates transcription of androgen-responsive genes.
The AR signaling pathway plays a crucial role in the development and function of male reproductive organs such as the prostate and epididymis, and also in nonreproductive organs including muscle, hair follicles, and brain.
Androgen Receptor is a phosphoprotein that regulates MAP kinase activity. Inhibition of the MEK1/2 pathway directly correlates with changes in AR phosphorylation.
Abnormalities in AR signaling are associated with diseases such as prostate cancer, Kennedy’s disease, and male infertility. Mutations in this gene cause complete androgen insensitivity (CAIS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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