Thermo Fisher Scientific MCM7 Monoclonal Antibody (15E1)
Thermo Fisher Scientific의 MCM7 Monoclonal Antibody (15E1)은 인간 MCM7 단백질을 인식하는 마우스 IgG1 항체로, Western blot, IHC, Flow cytometry에 사용 가능. 고순도 Protein A 정제, 액상 형태로 안정적인 저장 조건 제공. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 15E1 |
| Immunogen | Recombinant protein within Human MCM7 (aa 516–719) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | −20°C, avoid freeze/thaw cycles, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2848847 |
Product Specific Information
Positive Controls: HL-60 cell, 293 cell, PC-12 cell, K562 cell, human tonsil tissue, human esophagus tissue, SH-SY5Y cell.
Target Information
MCM7 encodes a protein that is one of the highly conserved mini-chromosome maintenance proteins (MCM) essential for the initiation of eukaryotic genome replication. The hexameric MCM complex is a key component of the pre-replication complex (pre_RC), involved in replication fork formation and recruitment of DNA replication-related proteins.
The MCM complex (including MCM2, 4, and 6) possesses DNA helicase activity and acts as a DNA unwinding enzyme. Cyclin D1-dependent kinase CDK4 associates with MCM7, potentially regulating its binding with tumor suppressor protein RB1/RB.
Alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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