Thermo Fisher Scientific Steroidogenic Factor 1 (SF-1) Recombinant Rabbit Monoclonal Antibody (NR5A1/4368R)
Recombinant rabbit monoclonal antibody targeting SF-1 (NR5A1/4368R). Validated for IHC applications in human and rat samples. High purity via Protein A/G purification. Supplied as liquid, 200 µg/mL concentration, stored at 4°C. For research use only.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | NR5A1/4368R |
| Immunogen | Recombinant fragment of human SF-1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Steroidogenic factor-1 (SF-1) is an orphan nuclear receptor involved in organ development and differentiation of the endocrine system. It is essential for fetal development of the hypothalamus, pituitary gland, gonads, and adrenal gland. SF-1 promotes transcriptional activity of many steroidogenic enzymes from the cytochrome P450 family.
SF-1 contains two activation function domains, AF1 and AF2, common to many nuclear steroid receptors. These domains are necessary for interaction with other nuclear receptors as well as coactivators and corepressors, including steroid receptor coactivator-1 (SRC-1), glucocorticoid receptor interacting protein 1 (GRIP1), cAMP response element binding protein (CREB) binding protein (CBP), and silencing mediator of retinoid acid and thyroid hormone receptor (SMRT).
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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