Thermo Fisher Scientific PrP Polyclonal Antibody
Bovine 및 Sheep 시료에 반응하는 Rabbit Polyclonal PrP 항체. Western blot에 적합하며, 단백질 G로 정제된 액상 항체. Prion 단백질 연구용으로 사용. 단기 4°C, 장기 -20°C 보관 권장.
- 카탈로그번호
- PA141673
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): 0.5–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Sheep |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 217–229 of BSE |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 0.2% gelatin |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2237759 |
Product Specific Information
- Suggested positive control: recombinant fusion protein.
Target Information
Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associated with lipid raft components and functions as a signaling molecule.
PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells, and in distribution of junction-associated proteins in human enterocytes.
Conversion of the normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step associated with the pathogenesis of prion neurodegenerative disorders, such as Creutzfeld-Jakob disease (CJD).
Whereas PrPc is rich in alpha-helices, the PrPSc form has a higher content of beta-sheets and is resistant to proteinase K.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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