Thermo Fisher Scientific CD4 Monoclonal Antibody (OKT4 (OKT-4)), Functional Grade, eBioscience
인간 CD4 항원을 인식하는 OKT4 단클론 항체로, Flow Cytometry 및 Immunoprecipitation에 적합합니다. HIV 수용체 연구와 T 세포 분석에 활용되며, Functional Grade로 높은 순도와 낮은 엔도톡신 수준을 제공합니다.
- 카탈로그번호
- 16-0048-xxx (5개 옵션)
- 판매단위
- pk
카탈로그
5개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD4 Monoclonal Antibody (OKT4 (OKT-4)), Functional Grade, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 1 publication |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Flow Cytometry (Flow) | 1 µg/test | View 30 publications |
| Immunoprecipitation (IP) | Assay-Dependent | - |
| Functional Assay | Assay-Dependent | - |
| Control (Ctrl) | Assay-Dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Published Species | Hamster, Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Recommended Isotype Control | Mouse IgG2b kappa Isotype Control (eBMG2b), Functional Grade, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OKT4 (OKT-4) |
| Conjugate | Functional Grade |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2865597 |
Available Conjugate Formats
- Unconjugated
- Alexa Fluor 488
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Biotin
- Brilliant UV 661
- Brilliant Violet 650
- Brilliant Violet 786
- eFluor 450
- eFluor 660
- FITC
- NovaFluor Blue 610-70S
- NovaFluor Blue 660-120S
- NovaFluor Blue 690
- NovaFluor Yellow 660
- PE
- PE-Cyanine7
- PerCP-Cyanine5.5
- Super Bright 436
- Super Bright 600
- Super Bright 702
- Request custom conjugation
Product Specific Information
Description:
The OKT4 monoclonal antibody reacts with human CD4, a 59 kDa cell surface glycoprotein expressed by most thymocytes, a subpopulation of mature T-helper cells, and at low levels on monocytes. CD4 acts as a receptor for HIV. The OKT4 antibody recognizes a different epitope than the RPA-T4 antibody, and these do not cross-block each other.
Applications Reported:
- Flow cytometric analysis
- Immunoprecipitation
Applications Tested:
Tested by flow cytometric analysis of normal human peripheral blood cells. Recommended ≤1 µg per test (100 µL final volume). Cell number may range from 10⁵ to 10⁸ cells/test. Antibody titration is recommended for optimal performance.
Storage and Handling:
Use in sterile environment.
Filtration:
0.2 µm post-manufacturing filtered.
Purity:
90%, determined by SDS-PAGE.
Endotoxin Level:
<0.001 ng/µg antibody (LAL assay).
Aggregation:
<10%, determined by HPLC.
Target Information
CD4 antigen recognizes MHC class II molecules and serves as a co-receptor for HIV. It is primarily expressed on T-helper lymphocytes but also found on monocytes, macrophages, and dendritic cells. CD4 expression is observed in thymus, lymph nodes, tonsils, spleen, and some non-lymphoid tissues such as brain and gut. It participates in T-cell activation through association with the T-cell receptor complex and Lck kinase. CD4 may also mediate neuronal damage in infectious and immune-mediated CNS diseases. Multiple alternatively spliced transcripts have been identified (RefSeq, July 2017).
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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