Thermo Fisher Scientific CD45 Monoclonal Antibody (CC1)
Thermo Fisher Scientific CD45 Monoclonal Antibody (CC1)은 소(Bovine) CD45 항원을 인식하는 Mouse IgG1 단일클론 항체입니다. IHC(F), Flow Cytometry, IP에 사용 가능하며, Protein A로 정제된 액상 형태입니다. 면역세포 표지 및 신호전달 연구에 적합합니다.
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Applications
Immunohistochemistry (Frozen) (IHC (F))
- Tested Dilution: Assay-dependent
Flow Cytometry (Flow)
- Tested Dilution: 1:25–1:200
Immunoprecipitation (IP)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CC1 |
| Immunogen | Bovine thoracic duct lymphocytes |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745351 |
Additional Formats
Product Specific Information
Mouse anti-Bovine CD45 antibody, clone CC1 recognizes the bovine homologue of the human CD45 antigen, also known as leucocyte common antigen (LCA). It is a pan-leucocyte surface marker expressed on all cells of hematopoietic origin except erythrocytes (Bembridge et al., 1993).
Target Information
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) expressed in all nucleated hematopoietic cells, comprising about 10% of lymphocyte surface proteins. It is absent in non-hematopoietic cells and tissues.
CD45 glycoprotein is essential for lymphocyte development and antigen signaling, regulating Src-family kinases. Multiple isoforms exist due to alternative splicing, differing in extracellular domains but sharing identical transmembrane and cytoplasmic domains.
CD45RA, one isoform, shows restricted expression among lymphoid cell subtypes. Isoforms differ in membrane localization and expression depending on cell type and state.
CD45 regulates T- and B-cell receptor signaling, suppresses JAK kinases, and modulates integrin-mediated pathways, apoptosis, and various immunological functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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