Thermo Fisher Scientific MAVS/VISA Polyclonal Antibody

Applications

Western Blot (WB)

• Assay-dependent

Immunoprecipitation (IP)

• 2–5 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt.

Target Information

Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway relies on members of the Toll-like receptor (TLR) family, while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA to trigger the immune response.
MAVS is a mitochondrial membrane protein that plays a critical role in IFN-beta signaling by recruiting IRF-3 to RIG-I, leading to activation of NF-kappa-B.
MAVS interacts with components of the innate immune pathway such as TLR adapter protein TRIF, TRAF2, and TRAF6, as well as kinases IKK-alpha, IKK-beta, and IKK-iota through its C-terminal region.
Cleavage of this region by Hepatitis C virus (HCV) protease enables HCV to evade the host immune system. Multiple isoforms of MAVS are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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