Thermo Fisher Scientific MAVS/VISA Polyclonal Antibody
MAVS/VISA 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF, IP 등 다양한 응용에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태. 인체 반응성, 4°C 보관.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific MAVS/VISA Polyclonal Antibody
Thermo Fisher Scientific MAVS/VISA Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 150 and 200 of human Mitochondrial Anti-Viral Signaling Protein (Virus-Induced Signaling Adapter) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note:
- For ICC, epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE cell sections.
- For IHC, epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.
Target Information
Two distinct signaling pathways activate host innate immunity against viral infection. One pathway relies on members of the Toll-like receptor (TLR) family, while the other uses RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA. MAVS is a mitochondrial membrane protein critical for IFN beta signaling, recruiting IRF-3 to RIG-I, leading to activation of NF-kappa-B. MAVS interacts with TLR adapter protein TRIF, TRAF2, TRAF6, and kinases IKK-alpha, IKK-beta, and IKK-iota. Cleavage of its C-terminal region by Hepatitis C virus protease allows viral immune evasion. Multiple isoforms of MAVS are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.