Thermo Fisher Scientific MAVS/VISA Polyclonal Antibody
MAVS/VISA 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF, IP 등 다양한 응용에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태. 인체 반응성, 4°C 보관.
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Thermo Fisher Scientific MAVS/VISA Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 150 and 200 of human Mitochondrial Anti-Viral Signaling Protein (Virus-Induced Signaling Adapter) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note:
- For ICC, epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE cell sections.
- For IHC, epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.
Target Information
Two distinct signaling pathways activate host innate immunity against viral infection. One pathway relies on members of the Toll-like receptor (TLR) family, while the other uses RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA. MAVS is a mitochondrial membrane protein critical for IFN beta signaling, recruiting IRF-3 to RIG-I, leading to activation of NF-kappa-B. MAVS interacts with TLR adapter protein TRIF, TRAF2, TRAF6, and kinases IKK-alpha, IKK-beta, and IKK-iota. Cleavage of its C-terminal region by Hepatitis C virus protease allows viral immune evasion. Multiple isoforms of MAVS are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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