Thermo Fisher Scientific IL8 Monoclonal Antibody (4G11)
인간 IL-8 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot, ELISA, Immunoprecipitation에 적합. 고순도 친화 크로마토그래피 정제, PBS 버퍼에 보존. 염증 및 종양 연구용으로 적합한 비결합형 항체.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 10 µg/mL |
| ELISA | 10 µg/mL |
| Immunoprecipitation (IP) | 10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4G11 |
| Immunogen | IL8 (AAH13615, 21 a.a. – approximately 99 a.a) full length recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
EGAVLPRSAK ELRCQCIKTY SKPFHPKFIK ELRVIESGPH CANTEIIVKL SDGRELCLDP KENWVQRVVE KFLKRAENS
Target Information
Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor belonging to the CXC chemokine subfamily. It binds to cell surface receptors IL-8RA and IL-8RB and functions as a chemoattractant and potent angiogenic factor.
IL-8 expression and secretion can be induced by diverse inflammatory stimuli in many cell types, including macrophages and endothelial cells. In endothelial cells, IL-8 is stored in Weibel-Palade bodies.
Originally isolated from osteosarcoma cells, IL-8 contains the ELR-motif (N-terminal Glu-Leu-Arg sequence) and signals through CXCR1 and CXCR2 receptors.
Previous nomenclature includes neutrophil activating protein 1 (NAP-1), granulocyte chemotactic protein 1 (GCP-1), monocyte-derived neutrophil-activating peptide (MONAP), and protein 3-10C.
IL-8 and ten other members of the CXC chemokine gene family form a cluster mapped to chromosome 4q. Cancer studies indicate IL-8 plays a role in tumor angiogenesis and growth, as well as in the pathogenesis of bronchiolitis caused by viral infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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