Thermo Fisher Scientific BAI1 Polyclonal Antibody
BAI1 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 및 ELISA에 사용 가능. 인간, 소, 영장류 등 다양한 종에 반응. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼에 0.1% sodium azide 포함. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 10–15 µg/mL |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from N-terminus of human BAI1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.7 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550136 |
Product Specific Information
- Percent identity with other species by BLAST analysis:
Human, Gorilla, Gibbon, Monkey, Bovine (100%); Mouse, Dog, Hamster, Elephant, Panda (94%); Marmoset (89%); Opossum (83%). - For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer.
After incubation with the primary antibody, slides were treated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
Adgrb1 (also known as BAI1) is a phosphatidylserine receptor that enhances the engulfment of apoptotic cells and likely acts as a potent inhibitor of angiogenesis in the brain. It may function in cell adhesion and signal transduction, playing a role as a mediator of the p53 signal in suppression of glioblastoma.
Angiogenesis is regulated by a balance between stimulators and inhibitors of new vessel growth and is essential for tumor growth and metastasis. Adgrb1 contains a functional p53-binding site and is transcriptionally regulated by wild-type p53. It belongs to the secretin receptor family and functions as an angiogenesis inhibitor and tumor growth suppressor. Diseases associated with ADGRB1 include glioblastoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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