Thermo Fisher Scientific Phospho-MAP2K4 (Ser257) Recombinant Rabbit Monoclonal Antibody (SEK1MKK4S257-C5)
MAP2K4(Ser257) 인산화 부위를 인식하는 재조합 토끼 단클론 항체로, Western blot 및 유세포분석에 적합합니다. HEK293 세포에서 발현되었으며, Protein A/G로 정제되었습니다. 인간, 마우스, 비인간 영장류 시료에 반응합니다.
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Applications
Western Blot (WB)
- Assay-dependent
Flow Cytometry (Flow)
- 1–1,000 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SEK1MKK4S257-C5 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Ser257 of human phospho SEK1/MKK4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.10% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897071 |
Additional Formats
Target Information
MAP2K4 (MEK4) serine/threonine kinase (mitogen-activated protein kinase 4) MEK4 or MKK4 is a dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and -2 as well as p38. MAP2K4 preferentially phosphorylates the tyrosine residue of JNKs. MAP2K4 mediates various physiological and pathophysiological processes such as responses to cellular stresses and inflammatory cytokines. It plays an important role in carcinogenesis; loss-of-function mutations have been identified in lung and pancreatic tumors, while pro-oncogenic roles have also been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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