Thermo Fisher Scientific ARHGAP20 Polyclonal Antibody
ARHGAP20 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot에 적합합니다. 인간 및 랫트 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, 단기 4°C, 장기 -20°C 보관이 권장됩니다.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues in Human ARHGAP20 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2719531 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
ARHGAP20 is a potent GTPase-activating protein (GAP) that converts Rho-type GTPases into an inactive GDP-bound state. It contains a pleckstrin homology (PH) domain, a Ras-associating domain, a Rho-GAP domain, and two Annexin-like (ANXL) repeats. ARHGAP20 acts as a direct downstream target of Rap1 in neurite outgrowth, where its overexpression promotes neurite extension in a Rap1-dependent manner by inactivating Rho. This gene functions as a tumor suppressor, being inactivated by deletion in breast cancer and by chromosomal translocation in B-cell chronic lymphocytic leukemia. It is implicated in cytoskeletal rearrangement and cell signaling during spermatogenesis. Expression is predominant in the human brain, liver, ovary, and spinal cord, with lower levels in lymph nodes and fetal liver.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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