Thermo Fisher Scientific WISP2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total WISP2.

Target Information

WISP2 is a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family.
WNT1 proteins are cysteine-rich, glycosylated signaling molecules mediating diverse developmental processes.
CTGF family members share four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain, and a C-terminal cystine knot-like (CT) domain.
WISP2 lacks the CT domain, which is involved in dimerization and heparin binding. It shows 72% amino acid identity with the mouse protein.
This gene may act downstream in the WNT1 signaling pathway relevant to malignant transformation.
Its expression is reduced in colon tumors, while other WISP members are overexpressed.
WISP2 is highly expressed in bone tissue and may play a role in bone turnover regulation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.