Thermo Fisher Scientific ABHD13 Polyclonal Antibody

Thermo Fisher Scientific ABHD13 Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1:1,000–1:3,000

Product Specifications

Product Specific Information

Predicted to react with Human samples.

Target Information

The α/β hydrolase superfamily comprises diverse members involved in important biochemical processes and various diseases. Despite having unrelated sequences, diverse substrates, and different catalytic activities, they share the canonical α/β hydrolase fold, consisting of an eight-stranded parallel α/β structure.
These enzymes are characterized by a catalytic triad composed of a histidine, an acid, and a nucleophile. Members of this superfamily are often drug targets for diseases such as diabetes, Alzheimer’s disease, obesity, and blood clotting disorders.

The Ab hydrolase domain containing (ABHD) gene subfamily includes 15 mostly uncharacterized members, most of which utilize a serine nucleophile forming the G-X-S-X-G nucleophile elbow.

• ABHD1: Metabolizes smoking xenobiotics
• ABHD2: Participates in the development of atherosclerosis
• ABHD4: Involved in an alternative synthesis pathway of NAE
• ABHD5: Mutations contribute to Chanarin-Dorfman syndrome
• ABHD6: May play a role in nervous system metabolism and signaling
• ABHD13: A 337 amino acid single-pass membrane protein belonging to the ABHD family

Usage Notice

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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