Thermo Fisher Scientific PSMD3 Polyclonal Antibody, Alexa Fluor 647

Applications

• Immunocytochemistry (ICC/IF)
  Tested Dilution: 1–10 µg/mL

Product Specifications

Product Specific Information

PA1974A647 detects proteasome 19S subunit S3 from human and mouse cells.
The immunizing peptide corresponds to amino acid residues 513–534 from human proteasome 19S subunit S3 protein.

Target Information

The 26S proteasome is a multicatalytic proteinase complex composed of two subcomplexes: a 20S core and a 19S regulator.

• The 20S core consists of four rings of 28 non-identical subunits (two rings of 7 alpha and two rings of 7 beta subunits).
• The 19S regulator includes a base (6 ATPase and 2 non-ATPase subunits) and a lid (up to 10 non-ATPase subunits).
  Proteasomes are abundant in eukaryotic cells and cleave peptides in an ATP/ubiquitin-dependent, non-lysosomal pathway.
  The immunoproteasome plays an essential role in processing class I MHC peptides.
  This gene encodes one of the non-ATPase subunits of the 19S regulator lid.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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