Thermo Fisher Scientific PSMD5 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1.0 µg/mL

-

Immunocytochemistry (ICC/IF)

2 µg/mL

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic Peptide: L(485) S E G P Y Y V K P V S T T A V E G A E(504) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PSMD5,uniProtId:Q16401-1,ncbiNodeId:9606,antigenRange:259-274,antigenLength:504,antigenImageFileName:PA1-975_PSMD5_Q16401-1_Rabbit.svg,antigenImageFileNamePDP:PA1-975_PSMD5_Q16401-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2170773

Product Specific Information

PA1-975 detects purified human proteasome 19S subunit S5b.

PA1-975 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~55 kDa protein representing purified human proteasome 19S subunit S5b.

PA1-975 immunizing peptide corresponds to amino acid residues 485-504 from human proteasome 19S subunit S5b protein.

Target Information

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator base.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.