Thermo Fisher Scientific PDHA1 Polyclonal Antibody
Thermo Fisher Scientific의 PDHA1 폴리클로날 항체는 인간 PDHA1 단백질을 특이적으로 인식합니다. 면역조직화학(IHC)에서 1:500~1:1,000 희석으로 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS 기반 저장용액과 함께 제공되며 연구용으로 적합합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PDHA1. Recombinant protein control fragment (Product #RP-104537). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856969 |
Product Specific Information
- Immunogen sequence: YCRSGKGPIL MELQTYRYHG HSMSDPGVS
Target Information
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO₂, providing the primary link between glycolysis and the tricarboxylic acid (TCA) cycle.
The PDH complex is composed of multiple copies of three enzymatic components:
- Pyruvate dehydrogenase (E1)
- Dihydrolipoamide acetyltransferase (E2)
- Lipoamide dehydrogenase (E3)
The E1 enzyme is a heterotetramer of two alpha and two beta subunits.
This gene encodes the E1 alpha 1 subunit containing the E1 active site and plays a key role in the function of the PDH complex.
Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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